He is required to attend Melbourne Magistrates Court each day of the four-week long committal hearing.
Cardinal Pell strongly denies all the allegations against him, and his lawyer has already informed the court he will officially be pleading not guilty.
The trial is the first time such a senior figure in the Holy See has faced criminal charges.
Pell's first appearance in Melbourne last July played host to an international media contingent of more than 100 reporters, court artists, television crews and photographers who'd gathered at the steps of the court.
The first two weeks of this month's committal are expected to hear solely from the accusers in a closed court. The remaining two weeks will be dedicated to the cross-examination of at least 40 other witnesses.
Committal "will be distressing" for complainants
Some law experts and advocates say they are concerned the public won't get full transparency when evidence is given in the closed court. They also fear the experience will likely be "distressing" for the complainants as their testimony is tested by the 76-year-old's defense team.
The accusers will give evidence by video link from a remote location. They'll be cross-examined by Pell's criminal defence barrister, Robert Richter, who is well known in Australia for his lengthy and forensic questioning of witnesses.
Professor Jeremy Gans, who teaches on all aspects of the criminal justice system at Melbourne University, told CNN there are services in place to help complainants try to prepare to be cross-examined, but it's not an easy process.
"The experience is likely to be very distressing," he said. "But the whole process of bringing a complaint is distressing. This is just one part of that."
Carol Stingel, who was cross-examined by Richter for four days as part of her 2007 civil rape case against Aboriginal leader Geoff Clark, told CNN the experience was so devastating she believes she should have been treated in the hospital afterwards.
But she also said that it was necessary to have her story heard.
"Richter is very good at what he does and delves into the tiniest details. It destroys the very essence of your being," she said. "I relied on evening primrose oil, coffee and cigarettes just to get through it."
"But at the same time," she said, "I felt I was being heard and being listened to at last, so in a way it's a sort of therapy, even though it's mentally and physically draining."
In a rare interview, Richter said he believes Pell is innocent and intends to show that "what was alleged was impossible."
He said he doesn't try to come to terms with the possible suffering of those he questions in court.
"I put it out of my mind, you say to yourself: 'I'm a professional,'" Richter told The Age newspaper. "People are hurt no matter what happens. If someone is wrongly convicted, or given a disproportionately heavy sentence, all you have done is multiply the number of victims."
Concerns for transparency
Once the committal is over, the magistrate will decide if there is enough evidence to go to trial in a higher court.
"A committal hearing has a similar purpose to a Grand Jury hearing in the US," Gans explained. "It's a way to test whether there is enough evidence to go ahead with a serious trial. The major difference is that a committal hearing is heard by a single magistrate (a legally qualified lower-ranked judge), rather than a jury."
Ingrid Irwin, an Australian lawyer who works in the area of historic sexual abuse in Pell's hometown of Ballarat, Victoria, says it's a "great flaw" that in the Australian legal system, the complainants don't have their own lawyers.
"Alleged victims do not have a lawyer during the criminal case so they are not a party to proceeding yet the case is all about them," she told CNN. "It seems unjust that the matter is about them, and they are not represented."
Pell's legal team prepared for case
At several short court hearings in the past four months, Pell's team has lodged court orders for documents and materials to help their case.
Pell's legal team successfully won its bid to raise undisclosed materials from a victims advocacy group, the Victorian police force, the Australian Broadcasting Corporation and lawyers involved in the area of historic sexual abuse, as well as from the complainants themselves.
Magistrate Belinda Wallington ruled in February however, that the medical records of the complainants could not be supplied as requested, for privacy reasons.
Her decision came after the prosecution team accused Pell's lawyers of going on a "fishing expedition" for personal medical information about the accusers, particularly in the area of mental health.
In January, a complainant in the case passed away and the prosecution requested the charge relating to him should be dropped.
The defence team argued to keep the charge in place, saying they would show the accuser prompted a "domino effect" of other alleged victims later coming forward because he was interviewed in the media.
However, at a hearing Friday, the prosecution announced the charge had been dropped.
Pell's secret location in Australia
In an exclusive report in January, CNN revealed that Pell was staying in a Sydney seminary with 40 trainee priests while he contests the case.
A spokesman said at the time that the cardinal had no official role at the seminary, where life for the trainees includes a strict daily regimen of prayer and teaching.
Pell had also previously served as archbishop of Melbourne and archbishop of Sydney before moving to Rome in 2014. He was soon appointed to the senior position of prefect of the secretariat for the economy and became a trusted figure close to Pope Francis.
At a news conference at the Vatican in June last year when he was charged, Pell said he had been the victim of "relentless character assassination."
"I'm innocent of these charges, they are false," Pell said. "The whole idea of sexual abuse is abhorrent to me."
Catholic Church under pressure
In December, the Catholic Church in Australia came under pressure from advocates after the country's Royal Commission into Institutional Responses to Child Sexual Abuse released its final report.
The Catholic Church was the sole target of about 20 recommendations, outlining what would amount to be a radical shakeup of centuries of tradition and orthodoxy. It included the recommendation that celibacy -- compulsory for Catholic priests -- should be voluntary.